Development of Novel Diclofenac Analogs Designed to Avoid Metabolic Activation and Hepatocyte Toxicity
Author:
Affiliation:
1. Faculty of Pharmacy, Keio University, 1-5-30 Shibakoen, Minato-ku, Tokyo 105-8512, Japan
2. Department of Chemistry, Nippon Medical School, 1-7-1 Kyonan-cho, Musashino, Tokyo 180-0023, Japan
Funder
Japan Science Society
Japan Agency for Medical Research and Development
Japan Society for the Promotion of Science
Hoansha Foundation
Publisher
American Chemical Society (ACS)
Subject
General Chemical Engineering,General Chemistry
Link
http://pubs.acs.org/doi/pdf/10.1021/acsomega.0c04942
Reference39 articles.
1. Quantitative studies of the risk of serious hepatic injury in persons using nonsteroidal antiinflammatory drugs
2. How Common Is Diclofenac-Associated Liver Injury? Analysis of 17,289 Arthritis Patients in a Long-Term Prospective Clinical Trial
3. Diclofenac-induced liver injury: a paradigm of idiosyncratic drug toxicity
4. Idiosyncratic Adverse Drug Reactions: Current Concepts
5. Immunochemical Identification of Mouse Hepatic Protein Adducts Derived from the Nonsteroidal Anti-Inflammatory Drugs Diclofenac, Sulindac, and Ibuprofen
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