Discovery of Anilino-1,4-naphthoquinones as Potent EGFR Tyrosine Kinase Inhibitors: Synthesis, Biological Evaluation, and Comprehensive Molecular Modeling

Author:

Mahalapbutr Panupong1ORCID,Leechaisit Ronnakorn2,Thongnum Anusit3ORCID,Todsaporn Duangjai4,Prachayasittikul Veda5ORCID,Rungrotmongkol Thanyada46,Prachayasittikul Supaluk5,Ruchirawat Somsak78,Prachayasittikul Virapong9,Pingaew Ratchanok2ORCID

Affiliation:

1. Department of Biochemistry, and Center for Translational Medicine, Faculty of Medicine, Khon Kaen University, Khon Kaen 40002, Thailand

2. Department of Chemistry, Faculty of Science, Srinakharinwirot University, Bangkok 10110, Thailand

3. Department of Physics, Faculty of Science, Srinakharinwirot University, Bangkok 10110, Thailand

4. Structural and Computational Biology Research Unit, Department of Biochemistry, Faculty of Science, Chulalongkorn University, Bangkok 10330, Thailand

5. Center of Data Mining and Biomedical Informatics, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand

6. Program in Bioinformatics and Computational Biology, Graduate School, Chulalongkorn University, Bangkok 10330, Thailand

7. Laboratory of Medicinal Chemistry and Program in Chemical Sciences, Chulabhorn Research Institute, Chulabhorn Graduate Institute, Bangkok 10210, Thailand

8. Commission on Higher Education, Ministry of Education, Center of Excellence on Environmental Health and Toxicology (EHT), Bangkok 10400, Thailand

9. Department of Clinical Microbiology and Applied Technology, Faculty of Medical Technology, Mahidol University, Bangkok 10700, Thailand

Funder

Khon Kaen University

Srinakharinwirot University

National Science, Research and Innovation Fund

Publisher

American Chemical Society (ACS)

Subject

General Chemical Engineering,General Chemistry

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