Dihydroquinoline Carbamate DQS1-02 as a Prodrug of a Potent Acetylcholinesterase Inhibitor for Alzheimer’s Disease Therapy: Multigram-Scale Synthesis, Mechanism Investigations, in Vitro Safety Pharmacology, and Preliminary in Vivo Toxicology Profile-Reference-Cited by-同舟云学术

Dihydroquinoline Carbamate DQS1-02 as a Prodrug of a Potent Acetylcholinesterase Inhibitor for Alzheimer’s Disease Therapy: Multigram-Scale Synthesis, Mechanism Investigations, in Vitro Safety Pharmacology, and Preliminary in Vivo Toxicology Profile

Published:2018-12-27 Issue:12 Volume:3 Page:18387-18397
ISSN:2470-1343
Container-title:ACS Omega
language:en
Short-container-title:ACS Omega

Author:

Alix Florent¹,Gembus Vincent¹^ORCID,Coquet Laurent²,Hubert-Roux Marie³,Chan Philippe²,Truong Lina³,Sebban Muriel³,Coadou Gaël³,Oulyadi Hassan³,Papamicaël Cyril³,Levacher Vincent³^ORCID

Affiliation:

1. VFP Therapies, R&D, 1 Rue Tesnière, 76130 Mont Saint Aignan, France

2. CNRS UMR6270, Normandie Université, UNIROUEN, Plateforme PISSARO, IRIB, Tremplin I2C, 76821 Rouen, France

3. Normandie Université, UNIROUEN, INSA Rouen, CNRS, COBRA, 76000 Rouen, France

Funder

Agence Nationale de la Recherche

Universit? de Rouen

Centre National de la Recherche Scientifique

Institut National des Sciences Appliqu?es Rouen

R?gion Haute-Normandie

Publisher

American Chemical Society (ACS)