Inhibition of 1-Deoxy-d-Xylulose-5-Phosphate Reductoisomerase by Lipophilic Phosphonates: SAR, QSAR, and Crystallographic Studies
Author:
Affiliation:
1. Department of Microbiology, Colorado State University, 1682 Campus Delivery, Ft. Collins, Colorado 80523, United States
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm200363d
Reference52 articles.
1. The Non-mevalonate Pathway of Isoprenoid Precursor Biosynthesis
2. Targeting the Methyl Erythritol Phosphate (MEP) Pathway for Novel Antimalarial, Antibacterial and Herbicidal Drug Discovery: Inhibition of 1-Deoxy-D-Xylulose-5-Phosphate Reductoisomerase (DXR) Enzyme
3. The MEP Pathway: A New Target for the Development of Herbicides, Antibiotics and Antimalarial Drugs
4. The Methylerythritol Phosphate Pathway and its Significance as a Novel Drug Target
5. 1-Deoxy- d -Xylulose 5-Phosphate Reductoisomerase (IspC) from Mycobacterium tuberculosis : towards Understanding Mycobacterial Resistance to Fosmidomycin
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