Synthesis and Evaluation of S-Acyl-2-thioethyl Esters of Modified Nucleoside 5‘-Monophosphates as Inhibitors of Hepatitis C Virus RNA Replication-Reference-Cited by-同舟云学术

Synthesis and Evaluation of S-Acyl-2-thioethyl Esters of Modified Nucleoside 5‘-Monophosphates as Inhibitors of Hepatitis C Virus RNA Replication

Published:2005-02-01 Issue:4 Volume:48 Page:1199-1210
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Prakash Thazha P.¹,Prhavc Marija¹,Eldrup Anne B.¹,Cook P. Dan¹,Carroll Steven S.¹,Olsen David B.¹,Stahlhut Mark W.¹,Tomassini Joanne E.¹,MacCoss Malcolm¹,Galloway Sheila M.¹,Hilliard Catherine¹,Bhat Balkrishen¹

Affiliation:

1. Department of Medicinal Chemistry, ISIS Pharmaceuticals, 2292 Faraday Avenue, Carlsbad, California 92008, Department of Biological Chemistry and Department of Safety Assessment, Merck Research Laboratories, West Point, Pennsylvania 19486, and Department of Medicinal Chemistry, Merck Research Laboratories, Rahway, New Jersey 07065

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0495172

Reference33 articles.

1. Resistance Profile of a Hepatitis C Virus RNA-Dependent RNA Polymerase Benzothiadiazine Inhibitor

2. Dose-finding study of interferon alfa-n3 in hepatitis

3. Current therapy and new molecular approaches to antiviral treatment and prevention of hepatitis C

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