Development of a Rule-Based Method for the Assessment of Protein Druggability
Author:
Affiliation:
1. Vertex Pharmaceuticals, 130 Waverly Street, Cambridge, Massachusetts 02139, United States
Publisher
American Chemical Society (ACS)
Subject
Library and Information Sciences,Computer Science Applications,General Chemical Engineering,General Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/ci200613b
Reference27 articles.
1. Rediscovering the sweet spot in drug discovery
2. Structure-based maximal affinity model predicts small-molecule druggability
3. Druggability Indices for Protein Targets Derived from NMR-Based Screening Data
4. Drug-like Density: A Method of Quantifying the “Bindability” of a Protein Target Based on a Very Large Set of Pockets and Drug-like Ligands from the Protein Data Bank
5. Identifying and Characterizing Binding Sites and Assessing Druggability
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