(R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropionamides Are Orally Active Inhibitors of Pyruvate Dehydrogenase Kinase-Reference-Cited by-同舟云学术

(R)-3,3,3-Trifluoro-2-hydroxy-2-methylpropionamides Are Orally Active Inhibitors of Pyruvate Dehydrogenase Kinase

Published:1999-07-01 Issue:15 Volume:42 Page:2741-2746
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Aicher Thomas D.¹,Anderson Robert C.¹,Bebernitz Gregory R.¹,Coppola Gary M.¹,Jewell Charles F.¹,Knorr Douglas C.¹,Liu Charles¹,Sperbeck Donald M.¹,Brand Leonard J.¹,Strohschein Robert J.¹,Gao Jiaping¹,Vinluan Christine C.¹,Shetty Suraj S.¹,Dragland Carol¹,Kaplan Emma L.¹,DelGrande Dominick¹,Islam Amin¹,Liu Xilin¹,Lozito Robert J.¹,Maniara Wieslawa M.¹,Walter R. Erik¹,Mann William R.¹

Affiliation:

1. Novartis Institute for Biomedical Research, 556 Morris Avenue, Summit, New Jersey 07901

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm9902584

Reference50 articles.

1. Inactivation of pyruvate dehydrogenase complex in heart muscle mitochondria of gold-thioglucose-induced obese mice is not due to a stable increase in activity of pyruvate dehydrogenase kinase

2. Active and inactive forms of pyruvate dehydrogenase in rat heart and kidney: Effect of diabetes, fasting, and refeeding on pyruvate dehydrogenase interconversion

3. Effect of starvation and insulin in vivo on the activity of the pyruvate dehydrogenase complex in rat skeletal muscles