Lead Optimization Providing a Series of Flavone Derivatives as Potent Nonsteroidal Inhibitors of the Cytochrome P450 Aromatase Enzyme-Reference-Cited by-同舟云学术

Lead Optimization Providing a Series of Flavone Derivatives as Potent Nonsteroidal Inhibitors of the Cytochrome P450 Aromatase Enzyme

Published:2006-06-30 Issue:15 Volume:49 Page:4777-4780
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Gobbi Silvia¹,Cavalli Andrea¹,Rampa Angela¹,Belluti Federica¹,Piazzi Lorna¹,Paluszcak Anja¹,Hartmann Rolf W.¹,Recanatini Maurizio¹,Bisi Alessandra¹

Affiliation:

1. Department of Pharmaceutical Sciences, University of Bologna, Via Belmeloro, 6, I-40126 Bologna, Italy, and Pharmaceutical and Medicinal Chemistry, Saarland University, P.O. Box 151150, D-66041 Saarbrücken, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm060186y

Reference14 articles.

1. The Effect of an Aromatase Inhibitor, 4-Hydroxy-4-Androstene- 3,17-Dione, On Estrogen-Dependent Processes in Reproduction and Breast Cancer11

2. Inhibition studies on the aromatization of androst-4-ene-3,17-dione by human placental microsomal preparations

3. Nonsteroidal aromatase inhibitors: Recent advances

4. Phase III Study of Letrozole Versus Tamoxifen as First-Line Therapy of Advanced Breast Cancer in Postmenopausal Women: Analysis of Survival and Update of Efficacy From the International Letrozole Breast Cancer Group

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