Tetrahydrochromenoimidazoles as Potassium-Competitive Acid Blockers (P-CABs): Structure−Activity Relationship of Their Antisecretory Properties and Their Affinity toward the hERG Channel-Reference-Cited by-同舟云学术

Tetrahydrochromenoimidazoles as Potassium-Competitive Acid Blockers (P-CABs): Structure−Activity Relationship of Their Antisecretory Properties and Their Affinity toward the hERG Channel

Published:2010-04-09 Issue:9 Volume:53 Page:3645-3674
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Palmer Andreas M.¹,Chiesa Vittoria¹,Schmid Anja¹,Münch Gabriela¹,Grobbel Burkhard¹,Zimmermann Peter J.¹,Brehm Christof¹,Buhr Wilm¹,Simon Wolfgang-Alexander¹,Kromer Wolfgang¹,Postius Stefan¹,Volz Jürgen¹,Hess Dietmar²

Affiliation:

1. NYCOMED GmbH, Departments of Medicinal Chemistry, Biochemistry, Pharmacology, and Physicochemistry, Byk-Gulden-Strasse 2, D-78467 Konstanz, Germany

2. NMI TT GmbH, Markwiesenstrasse 55, D-72770 Reutlingen, Germany

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm100040c

Reference37 articles.

1. Novel indanyl-substituted imidazo[1,2-a]pyridines as potent reversible inhibitors of the gastric H+/K+-ATPase

2. Preparation of tetrahydroimidazo[2,1-a]isoquinolines and their use as inhibitors of gastric acid secretion

3. Novel imidazo[1,2-a]pyrazine derivatives as potent reversible inhibitors of the gastric H+/K+-ATPase

4. 5-Substituted 1H-pyrrolo[3,2-b]pyridines as inhibitors of gastric acid secretion☆

5. Synthesis and Evaluation of 7H-8,9-Dihydropyrano[2,3-c]imidazo[1,2-a]pyridines as Potassium-Competitive Acid Blockers

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