A Large-Scale Synthesis of Enantiomerically Pure Cetirizine Dihydrochloride Using Preparative Chiral HPLC-Reference-Cited by-同舟云学术

A Large-Scale Synthesis of Enantiomerically Pure Cetirizine Dihydrochloride Using Preparative Chiral HPLC

Published:2000-12-08 Issue:2 Volume:5 Page:110-115
ISSN:1083-6160
Container-title:Organic Process Research & Development
language:en
Short-container-title:Org. Process Res. Dev.

Author:

Pflum Derek A.¹,Wilkinson H. Scott¹,Tanoury Gerald J.¹,Kessler Donald W.¹,Kraus Hali B.¹,Senanayake Chris H.¹,Wald Stephen A.¹

Affiliation:

1. Sepracor, Inc., Chemical Research and Development, 111 Locke Drive, Marlborough, Massachusetts 01752

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/op0002951

Reference6 articles.

1. A Novel Synthesis of the Enantiomers of an Antihistamine Drug by Piperazine Formation from a Primary Amine

2. Catalytic enantioselective synthesis of the second generation histamine antagonist cetirizine hydrochloride

3. The large-scale synthesis of racemic5and chiral HPLC separation were performed by Regis Technologies, 8210 Austin Ave, Morton Grove, IL 60053. The large-scale chiral HPLC was performed using an automated, computer-controlled isocratic/gradient preparative HPLC system and a Prochem LC150 column (40 × 15 cm) packed with Chiralpak AD packing material (2 kg).

Cited by 34 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Chiral Separations at Semi and Preparative Scale;Chiral Separations and Stereochemical Elucidation;2023-03-26

2. Enantioselective Intramolecular α‐Arylation of Benzylamine Derivatives: Synthesis of a Precursor to Levocetirizine;Angewandte Chemie International Edition;2023-02-23

3. Enantioselective Intramolecular α‐Arylation of Benzylamine Derivatives: Synthesis of a Precursor to Levocetirizine;Angewandte Chemie;2023-02-23

4. Large-Scale Amidations in Process Chemistry: Practical Considerations for Reagent Selection and Reaction Execution;Organic Process Research & Development;2022-06-07

5. Adsorption, Liquid Separation;Kirk‐Othmer Encyclopedia of Chemical Technology;2021-09-17