Combined Ion-Trapping and Mass Balance Models To Describe the pH-Dependent Uptake and Toxicity of Acidic and Basic Pharmaceuticals in Zebrafish Embryos (Danio rerio)-Reference-Cited by-同舟云学术

Combined Ion-Trapping and Mass Balance Models To Describe the pH-Dependent Uptake and Toxicity of Acidic and Basic Pharmaceuticals in Zebrafish Embryos (Danio rerio)

Published:2019-06-09 Issue:13 Volume:53 Page:7877-7886
ISSN:0013-936X
Container-title:Environmental Science & Technology
language:en
Short-container-title:Environ. Sci. Technol.

Author:

Bittner Lisa¹,Klüver Nils¹,Henneberger Luise¹^ORCID,Mühlenbrink Marie¹,Zarfl Christiane²^ORCID,Escher Beate I.¹²^ORCID

Affiliation:

1. Helmholtz Centre for Environmental Research − UFZ, Permoserstrasse 15, 04318 Leipzig, Germany

2. Eberhard Karls University of Tübingen, Center for Applied Geoscience, Hölderlinstrasse 12, 72074 Tübingen, Germany

Funder

German Federal Ministry of Education and Research (BMBF) and the German Research Foundation (DFG)

Innovative Medicines Initiative Joint Undertaking

Publisher

American Chemical Society (ACS)

Subject

Environmental Chemistry,General Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.est.9b02563

Reference57 articles.

1. Ranking REACH registered neutral, ionizable and ionic organic chemicals based on their aquatic persistency and mobility

2. The significance of acid/base properties in drug discovery

3. The effect of pH on the uptake and toxicity of the bivalent weak base chloroquine tested on Salix viminalis and Daphnia magna

4. The pH-dependent toxicity of basic pharmaceuticals in the green algae Scenedesmus vacuolatus can be explained with a toxicokinetic ion-trapping model

5. Critical evaluation and further development of methods for testing ecotoxicity at multiple pH using Daphnia magna and Pseudokirchneriella subcapitata

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