The Rate-Limiting Step in P450 Hydroxylation of Hydrocarbons A Direct Comparison of the “Somersault” versus the “Consensus” Mechanism Involving Compound I-Reference-Cited by-同舟云学术

The Rate-Limiting Step in P450 Hydroxylation of Hydrocarbons A Direct Comparison of the “Somersault” versus the “Consensus” Mechanism Involving Compound I

Published:2010-08-06 Issue:34 Volume:114 Page:9319-9332
ISSN:1089-5639
Container-title:The Journal of Physical Chemistry A
language:en
Short-container-title:J. Phys. Chem. A

Author:

Bach Robert D.¹

Affiliation:

1. Department of Chemistry and Biochemistry, University of Delaware, Newark, Delaware 19716

Publisher

American Chemical Society (ACS)

Subject

Physical and Theoretical Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jp1045518

Reference74 articles.

1. Hydrocarbon Hydroxylation by Cytochrome P450 Enzymes

2. P450 Enzymes: Their Structure, Reactivity, and Selectivity—Modeled by QM/MM Calculations

3. Oxidizing species in the mechanism of cytochrome P450

4. Models and mechanisms of O-O bond activation by cytochrome P450. A critical assessment of the potential role of multiple active intermediates in oxidative catalysis

5. Aliphatic hydroxylation via oxygen rebound. Oxygen transfer catalyzed by iron

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