Discovery of JND003 as a New Selective Estrogen-Related Receptor α Agonist Alleviating Nonalcoholic Fatty Liver Disease and Insulin Resistance

Author:

Mao Liufeng1,Peng Lijie2,Ren Xiaomei2,Chu Yi34,Nie Tao34,Lin Wanhua5,Libby Andrew6,Xu Yong34ORCID,Chang Yu2,Lei Chong2,Loomes Kerry7ORCID,Wang Na38,Liu Jinsong38ORCID,Levi Moshe6,Wu Donghai34,Hui Xiaoyan9,Ding Ke21011ORCID

Affiliation:

1. Scientific Research Center, The First Affiliated Hospital of Guangdong Pharmaceutical University, Nonglinxi Road 19, Guangzhou, Guangdong 510080, P. R. China

2. International Cooperative Laboratory of Traditional Chinese Medicine Modernization and Innovative Drug Development of Chinese Ministry of Education (MOE), School of Pharmacy, Jinan University, #855 Xingye Avenue, Guangzhou 510632, China

3. Guangzhou Institutes of Biomedicine and Health, #190 Kaiyuan Avenue, Guangzhou 510530, China

4. China-New Zealand Joint Laboratory on Biomedicine and Health, Guangzhou 510530, China

5. School of Life Sciences, Guangxi Normal University, Guilin 541004, China

6. Department of Biochemistry and Molecular & Cellular Biology, Basic Science 353, Georgetown University, 3900 Reservoir Road, Washington, District of Columbia 20057, United States

7. School of Biological Sciences and Maurice Wilkins Centre, University of Auckland, Auckland 1010, New Zealand

8. School of Life Sciences, University of Science and Technology of China, Hefei 230026, China

9. School of Biomedical Sciences, The Chinese University of Hong Kong, Kowloon, Hong Kong SAR 99077, China

10. The First Affiliated Hospital of Jinan University, Guangzhou 510630, China

11. State Key Laboratory of Bioorganic Chemistry and Natural Products, Shanghai Institute of Organic Chemistry, Chinese Academy of Sciences, Shanghai 210530, China

Funder

Guangzhou Regenerative Medicine and Health Guangdong Laboratory

Commonwealth Scientific and Industrial Research Organisation

National Natural Science Foundation of China

Chinese Academy of Sciences

Guangzhou City

Guangzhou International Collaborative Grant

Pearl River S&T Nova Program of Guangzhou

Publisher

American Chemical Society (ACS)

Subject

Pharmaceutical Science,Drug Discovery,Molecular Biology,Biochemistry

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