Potential Use of Supercharging Agents for Improved Mass Spectrometric Analysis of Monoclonal Antibodies and Antibody

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Potential Use of Supercharging Agents for Improved Mass Spectrometric Analysis of Monoclonal Antibodies and Antibody–Drug Conjugates

Published:2022-06-15 Issue:7 Volume:33 Page:1161-1167
ISSN:1044-0305
Container-title:Journal of the American Society for Mass Spectrometry
language:en
Short-container-title:J. Am. Soc. Mass Spectrom.

Author:

Källsten Malin¹²,Visanu Diana²,Pijnappel Matthijs²,Lehmann Fredrik³,Bergquist Jonas¹,Lind Sara Bergström¹^ORCID,Kovac Lucia²^ORCID

Affiliation:

1. Analytical Chemistry, Department of Chemistry-BMC, Uppsala University, S75237 Uppsala, Sweden

2. Recipharm OT Chemistry AB, S75450 Uppsala, Sweden

3. OT Pharmaceuticals AB, S19134 Sollentuna, Sweden

Funder

Vetenskapsr?det

Stiftelsen f?r?Strategisk Forskning

Recipharm OT Chemistry AB

Publisher

American Chemical Society (ACS)

Subject

Spectroscopy,Structural Biology

Link

https://pubs.acs.org/doi/pdf/10.1021/jasms.2c00008

Reference35 articles.

1. Nanoparticle systems reduce systemic toxicity in cancer treatment

2. Antibody-drug conjugates: recent advances in conjugation and linker chemistries

3. The therapeutic monoclonal antibody market

4. Characterization of antibody–drug conjugates by mass spectrometry: advances and future trends

5. Qualitative analysis of antibody–drug conjugates (ADCs): an experimental comparison of analytical techniques of cysteine-linked ADCs

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