Conformationally Constrained Butyrophenones with Mixed Dopaminergic (D2) and Serotoninergic (5-HT2A, 5-HT2C) Affinities: Synthesis, Pharmacology, 3D-QSAR, and Molecular Modeling of (Aminoalkyl)benzo- and -thienocycloalkanones as Putative Atypical Antipsychotics-Reference-Cited by-同舟云学术

Conformationally Constrained Butyrophenones with Mixed Dopaminergic (D2) and Serotoninergic (5-HT2A, 5-HT2C) Affinities: Synthesis, Pharmacology, 3D-QSAR, and Molecular Modeling of (Aminoalkyl)benzo- and -thienocycloalkanones as Putative Atypical Antipsychotics

Published:1999-07-01 Issue:15 Volume:42 Page:2774-2797
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Raviña Enrique¹,Negreira Jesús¹,Cid José¹,Masaguer Christian F.¹,Rosa Elizabeth¹,Rivas M. Emilia¹,Fontenla José A.¹,Loza M. Isabel¹,Tristán Helena¹,Cadavid M. Isabel¹,Sanz Ferran¹,Lozoya Estrella¹,Carotti Angelo¹,Carrieri Antonio¹

Affiliation:

1. Departamento de Química Orgánica, Laboratorio de Química Farmacéutica, and Departamento de Farmacología, Facultad de Farmacia, Universidad de Santiago, E-15706 Santiago de Compostela, Spain, Departamento d'Informàtica Mèdica, Institut Municipal d'Investigació Mèdica, Universitat Pompeu Fabra, Dr. Aiguader 80, E-08003 Barcelona, Spain, and Dipartimento Farmaco Chimico, Università di Bari, I-70126 Bari, Italy

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm981094e

Reference90 articles.

1. Sitsen, A. Current trends in antipsychotic agents.Script Report; PJB Publications: Richmond, U.K., 1990; p 57.

2. Antipsychotic drug doses and neuroleptic/dopamine receptors

3. Association study of dopamine D3 receptor gene and schizophrenia

Cited by 37 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. “Selective” serotonin 5-HT2A receptor antagonists;Biochemical Pharmacology;2022-06

2. Computer-Aided Drug Design Approaches to Study Key Therapeutic Targets in Alzheimer’s Disease;Neuromethods;2017-09-28

3. Identification and preliminary structure–activity relationships of 1-Indanone derivatives as novel indoleamine-2,3-dioxygenase 1 (IDO1) inhibitors;Bioorganic & Medicinal Chemistry;2017-07

4. Rhodium(iii)-catalyzed synthesis of indanones via C–H activation of phenacyl phosphoniums and coupling with olefins;Organic Chemistry Frontiers;2017

5. Two Binding Geometries for Risperidone in Dopamine D3 Receptors: Insights on the Fast-Off Mechanism through Docking, Quantum Biochemistry, and Molecular Dynamics Simulations;ACS Chemical Neuroscience;2016-08-05