Mechanism-Based Inhibition of Human Steroid 5α-Reductase by Finasteride: Enzyme-Catalyzed Formation of NADP−Dihydrofinasteride, a Potent Bisubstrate Analog Inhibitor
Author:
Affiliation:
1. Contribution from the Merck Research Laboratories, Rahway, New Jersey, 07065
Publisher
American Chemical Society (ACS)
Subject
Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis
Link
https://pubs.acs.org/doi/pdf/10.1021/ja953069t
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1. The clinical development of a 5α-reductase inhibitor, finasteride
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3. Inhibitors of steroid 5α-reductase in benign prostatic hyperplasia, male pattern baldness and acne
4. Deletion of steroid 5α-reductase 2 gene in male pseudohermaphroditism
5. STEROID 5α-REDUCTASE: TWO GENES/TWO ENZYMES
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