Reengineering a Tryptophan Halogenase To Preferentially Chlorinate a Direct Alkaloid Precursor-Reference-Cited by-同舟云学术

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Reengineering a Tryptophan Halogenase To Preferentially Chlorinate a Direct Alkaloid Precursor

Published:2011-11-11 Issue:48 Volume:133 Page:19346-19349
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Glenn Weslee S.¹²,Nims Ezekiel²,O’Connor Sarah E.¹³

Affiliation:

1. Department of Biological Chemistry, The John Innes Centre, Norwich NR4 7UH, U.K.

2. Department of Chemistry, Massachusetts Institute of Technology, 77 Massachusetts Avenue, Cambridge, Massachusetts 02139, United States

3. The University of East Anglia, Norwich NR4 7TJ, U.K.

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/ja2089348

Reference21 articles.

1. Alkaloid Biosynthesis: The Basis for Metabolic Engineering of Medicinal Plants

2. Natural products in drug discovery

3. The Renaissance of Natural Products as Drug Candidates

4. Fluorinated Natural Products with Clinical Significance

5. Engineering Fluorometabolite Production: Fluorinase Expression in Salinispora tropica Yields Fluorosalinosporamide

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