Application of a Flexible Synthesis of (5R)-Thiolactomycin To Develop New Inhibitors of Type I Fatty Acid Synthase-Reference-Cited by-同舟云学术

Application of a Flexible Synthesis of (5R)-Thiolactomycin To Develop New Inhibitors of Type I Fatty Acid Synthase

Published:2005-01-20 Issue:4 Volume:48 Page:946-961
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

McFadden Jill M.¹,Medghalchi Susan M.¹,Thupari Jagan N.¹,Pinn Michael L.¹,Vadlamudi Aravinda¹,Miller Katherine I.¹,Kuhajda Francis P.¹,Townsend Craig A.¹

Affiliation:

1. Department of Chemistry, Johns Hopkins University, Baltimore, Maryland 21218, FASgen, Inc., Baltimore, Maryland 21224, and Department of Pathology, Johns Hopkins University School of Medicine, Baltimore, Maryland 21205

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm049389h

Reference58 articles.

1. Fatty acid synthesis: a potential selective target for antineoplastic therapy.

2. Haptoglobin-Related Protein (Hpr) Epitopes in Breast Cancer as a Predictor of Recurrence of the Disease

3. The prognostic value of oncogenic antigen 519 (OA-519) expression and proliferative activity detected by antibody MIB-I in node-negative breast cancer

4. A Fatty Acid Synthase Blockade Induces Tumor Cell-cycle Arrest by Down-regulating Skp2

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