1. CAS Key Laboratory of Marine Bio-resources Sustainable Utilization, RNAM Center for Marine Microbiology, Guangdong Key Laboratory of Marine Materia Medica, South China Sea Institute of Oceanology, Chinese Academy of Sciences, 164 West Xingang Road, Guangzhou 510301, China, Graduate University of the Chinese Academy of Sciences, Beijing 100049, China, and Département de Biochimie, de Microbiologie et de Bio-informatique, PROTEO et IBIS, Université Laval, Québec, G1V 0A6, Canada