Process Research and Development of a Dihydropyrimidine Dehydrogenase Inactivator: Large-Scale Preparation of Eniluracil Using a Sonogashira Coupling
Author:
Affiliation:
1. Chemical Development Division, GlaxoSmithKline Medicines Research Centre, Gunnels Wood Road, Stevenage, Hertfordshire. SG1 2NY, UK
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Physical and Theoretical Chemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/op0100100
Reference13 articles.
1. Mechanism-based inactivation of dihydropyrimidine dehydrogenase by 5-ethynyluracil.
2. 5-Ethynyluracil (776C85), a modulator of the therapeutic activity of 5-fluorouracil
3. Synthesis of 1-(2-deoxy-β--pentofuranosyl)-5-ethylnyl-1,2,3,4,-tetrahydropyrimidine-2,4-dione (5-ethynyl-2′-deoxyuridine)
4. Incorporation of 5-substituted uracil derivatives into nucleic acids. Part IV. The synthesis of 5-ethynyluracil
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