Inhibitors for Human Glutaminyl Cyclase by Structure Based Design and Bioisosteric Replacement
Author:
Affiliation:
1. Department of Medicinal Chemistry
2. Department of Bioorganic Chemistry, Leibniz Institute of Plant Biochemistry, Weinberg 3, D-06120 Halle, Germany
3. Department of Preclinical Pharmacology
4. Department of Enzymology
Publisher
American Chemical Society (ACS)
Subject
Drug Discovery,Molecular Medicine
Link
https://pubs.acs.org/doi/pdf/10.1021/jm900969p
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2. Pyroglutamic acid
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4. An enzyme(s) that converts glutaminyl-peptides into pyroglutamyl-peptides. Presence in pituitary, brain, adrenal medulla, and lymphocytes.
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