Glycomimetic, Orally Bioavailable LecB Inhibitors Block Biofilm Formation of Pseudomonas aeruginosa

Author:

Sommer Roman12,Wagner Stefanie12,Rox Katharina2,Varrot Annabelle3,Hauck Dirk12,Wamhoff Eike-Christian45,Schreiber Janine2,Ryckmans Thomas6,Brunner Thomas7,Rademacher Christoph45ORCID,Hartmann Rolf W.28ORCID,Brönstrup Mark2,Imberty Anne3,Titz Alexander128ORCID

Affiliation:

1. Chemical Biology of Carbohydrates and ‡Drug Design and Development, Helmholtz Institute for Pharmaceutical Research Saarland (HIPS), Helmholtz Centre for Infection Research (HZI), D-66123 Saarbrücken, Germany

2. Deutsches Zentrum für Infektionsforschung (DZIF), Standort Hannover-Braunschweig, Germany

3. Univ. Grenoble Alpes, CNRS, Centre de Recherche sur les Macromolécules Végétales (CERMAV), 38000 Grenoble, France

4. Department of Biomolecular Systems, Max Planck Institute of Colloids and Interfaces, D-14424 Potsdam, Germany

5. Department of Biology, Chemistry and Pharmacy, Freie Universität Berlin, D-14195 Berlin, Germany

6. Roche Pharmaceutical Research and Early Development, Roche Innovation Center Basel, CH-4070 Basel, Switzerland

7. Biochemical Pharmacology, Department of Biology, University of Konstanz, D-78457 Konstanz, Germany

8. Department of Pharmacy, Saarland University, D-66123 Saarbrücken, Germany

Funder

Agence Nationale de la Recherche

Deutscher Akademischer Austauschdienst

Helmholtz-Gemeinschaft

Deutsche Forschungsgemeinschaft

European Cooperation in Science and Technology

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Reference46 articles.

1. Control of an outbreak of carbapenem-resistant Pseudomonas aeruginosa in a haemato-oncology unit

2. Federal Funding for the Study of Antimicrobial Resistance in Nosocomial Pathogens: No ESKAPE

3. Genotypes and infection sites in an outbreak of multidrug-resistant Pseudomonas aeruginosa

4. World Health Organization. WHO publishes list of bacteria for which new antibiotics are urgently needed.http://www.who.int/mediacentre/news/releases/2017/bacteria-antibiotics-needed/en/(accessed May 2017).

5. Perspectives on Critical Care Infectious Diseases;Hauser A. R.,2003

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