Improved Total Synthesis of Tubulysins and Design, Synthesis, and Biological Evaluation of New Tubulysins with Highly Potent Cytotoxicities against Cancer Cells as Potential Payloads for Antibody

Improved Total Synthesis of Tubulysins and Design, Synthesis, and Biological Evaluation of New Tubulysins with Highly Potent Cytotoxicities against Cancer Cells as Potential Payloads for Antibody–Drug Conjugates

Published:2018-01-30 Issue:10 Volume:140 Page:3690-3711
ISSN:0002-7863
Container-title:Journal of the American Chemical Society
language:en
Short-container-title:J. Am. Chem. Soc.

Author:

Nicolaou K. C.¹^ORCID,Erande Rohan D.¹,Yin Jun¹,Vourloumis Dionisios¹²,Aujay Monette³,Sandoval Joseph³,Munneke Stefan³,Gavrilyuk Julia³

Affiliation:

1. Department of Chemistry, BioScience Research Collaborative, Rice University, 6100 Main Street, Houston, Texas 77005, United States

2. Laboratory of Chemical Biology of Natural Products & Designed Molecules, N.C.S.R “Demokritos”, 153 10 Agia Paraskevi, Athens, Greece

3. AbbVie Stemcentrx, LLC, 450 East Jamie Court, South San Francisco, California 94080, United States

Funder

Welch Foundation

Cancer Prevention and Research Institute of Texas

AbbVie Stemcentrx, LLC.

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

Link

https://pubs.acs.org/doi/pdf/10.1021/jacs.7b12692

Reference94 articles.

1. Myxobacterial epothilones and tubulysins as promising anticancer agents

2. Tubulysins, New Cytostatic Peptides from Myxobacteria Acting on Microtubuli. Production, Isolation, Physico-chemical and Biological Properties.

3. Identification and Analysis of the Core Biosynthetic Machinery of Tubulysin, a Potent Cytotoxin with Potential Anticancer Activity

4. Mechanism of Action of Tubulysin, an Antimitotic Peptide from Myxobacteria

5. The Tubulin-Bound Structure of the Antimitotic Drug Tubulysin

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