Synthesis of Terminal Ribose Analogues of Adenosine 5′-Diphosphate Ribose as Probes for the Transient Receptor Potential Cation Channel TRPM2-Reference-Cited by-同舟云学术

Synthesis of Terminal Ribose Analogues of Adenosine 5′-Diphosphate Ribose as Probes for the Transient Receptor Potential Cation Channel TRPM2

Published:2019-04-12 Issue:10 Volume:84 Page:6143-6157
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Baszczyňski Ondřej¹,Watt Joanna M.²¹,Rozewitz Monika D.³,Guse Andreas H.³,Fliegert Ralf³,Potter Barry V. L.²¹^ORCID

Affiliation:

1. Wolfson Laboratory of Medicinal Chemistry, Department of Pharmacy and Pharmacology, University of Bath, Bath BA2 7AY, U.K.

2. Medicinal Chemistry & Drug Discovery, Department of Pharmacology, University of Oxford, Mansfield Road, Oxford OX1 3QT, U.K.

3. The Calcium Signalling Group, Department of Biochemistry and Molecular Cell Biology, University Medical Center Hamburg-Eppendorf, Martinistrasse 52, 20246 Hamburg, Germany

Funder

Deutsche Forschungsgemeinschaft

Wellcome Trust

Landesforschungsf?rderung Hamburg

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acs.joc.9b00338

Reference45 articles.

1. ADP-ribose gating of the calcium-permeable LTRPC2 channel revealed by Nudix motif homology

2. NUDT9, a Member of the Nudix Hydrolase Family, Is an Evolutionarily Conserved Mitochondrial ADP-ribose Pyrophosphatase

3. The proposed channel-enzyme transient receptor potential melastatin 2 does not possess ADP ribose hydrolase activity

4. TRPM2 channel opening in response to oxidative stress is dependent on activation of poly(ADP-ribose) polymerase

5. The Poly(ADP-ribose) Polymerase PARP-1 Is Required for Oxidative Stress-induced TRPM2 Activation in Lymphocytes

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