Synthesis of Etrasimod (APD334): Al<sub>2</sub>O<sub>3</sub>-Promoted Decarboxylative Rearrangements of Cyclopentenones with Stereochemical Inversion-Reference-Cited by-同舟云学术

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Synthesis of Etrasimod (APD334): Al₂O₃-Promoted Decarboxylative Rearrangements of Cyclopentenones with Stereochemical Inversion

Published:2024-08-16 Issue:17 Volume:89 Page:12524-12532
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Hsu Ju-Hsuan¹,Leung TszIn¹,Wu Yang-Chang²,Lai Chin-Hung³^ORCID,El Bakri Youness⁴^ORCID,Chang Chi-Fen⁵,Chuang Ta-Hsien¹^ORCID

Affiliation:

1. School of Pharmacy, China Medical University, Taichung 406040, Taiwan

2. Chinese Medicine Research and Development Center, China Medical University Hospital, Taichung 404394, Taiwan

3. Department of Medical Applied Chemistry, Chung Shan Medical University, Taichung 40201, Taiwan

4. Department of Theoretical and Applied Chemistry, South Ural State University, Chelyabinsk 454080, Russia Federation

5. Department of Anatomy, School of Medicine, China Medical University, Taichung 40402, Taiwan

Funder

China Medical University, Taiwan

National Science and Technology Council

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.4c01463

Reference58 articles.

1. Efficacy and Safety of Etrasimod in a Phase 2 Randomized Trial of Patients With Ulcerative Colitis

2. Discovery of APD334: Design of a Clinical Stage Functional Antagonist of the Sphingosine-1-phosphate-1 Receptor

3. Modulation of sphingosine-1-phosphate in inflammatory bowel disease

4. Will novel oral formulations change the management of inflammatory bowel disease?

5. Design and synthesis of etrasimod derivatives as potent antibacterial agents against Gram-positive bacteria

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