General Synthesis of Conformationally Constrained Noncanonical Amino Acids with C(<i>sp</i><sup>3</sup>)-Rich Benzene Bioisosteres-Reference-Cited by-同舟云学术

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General Synthesis of Conformationally Constrained Noncanonical Amino Acids with C(sp³)-Rich Benzene Bioisosteres

Published:2024-03-27 Issue:7 Volume:89 Page:5010-5018
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Ma Xiaoshen¹^ORCID,Beard Adam M.¹,Burgess Samantha A.²^ORCID,Darlak Miroslawa¹,Newman Justin A.³^ORCID,Nogle Lisa M.¹,Pietrafitta Mark J.¹,Smith David A.¹,Wang Xiao³^ORCID,Yue Lei¹

Affiliation:

1. Department of Discovery Chemistry, Merck & Co., Inc., 33 Ave. Louis Pasteur, Boston, Massachusetts 02215, United States

2. Analytical Research & Development, Merck & Co., Inc., 33 Ave. Louis Pasteur, Boston, Massachusetts 02215, United States

3. Analytical Research and Development, Merck & Co., Inc., 126 E. Lincoln Ave., Rahway, New Jersey 07065, United States

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.4c00225

Reference67 articles.

1. New Chemical Modalities and Strategic Thinking in Early Drug Discovery

2. Advancing drug discovery using the power of the human genome

3. New Modalities for Challenging Targets in Drug Discovery

4. Steering New Drug Discovery Campaigns: Permeability, Solubility, and Physicochemical Properties in the bRo5 Chemical Space

5. Oral Druggable Space beyond the Rule of 5: Insights from Drugs and Clinical Candidates

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