Bringing Macrolactamization Full Circle: Self-Cleaving Head-to-Tail Macrocyclization of Unprotected Peptides via Mild N-Acyl Urea Activation-Reference-Cited by-同舟云学术

Bringing Macrolactamization Full Circle: Self-Cleaving Head-to-Tail Macrocyclization of Unprotected Peptides via Mild N-Acyl Urea Activation

Published:2018-12-19 Issue:2 Volume:84 Page:1035-1041
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Arbour Christine A.¹^ORCID,Belavek Kayla J.¹,Tariq Rooha¹,Mukherjee Subha²,Tom Janine K.³,Isidro-Llobet Albert⁴^ORCID,Kopach Michael E.⁵,Stockdill Jennifer L.¹^ORCID

Affiliation:

1. Department of Chemistry, Wayne State University, Detroit, Michigan 48202, United States

2. Bristol-Myers Squibb, Chemical and Synthetic Development, New Brunswick, New Jersey 08903, United States

3. Amgen, Inc., Pivotal Drug Substance Process Development, Thousand Oaks, California 91320, United States

4. GlaxoSmithKline, Medicines Research Centre, Stevenage SG1 2NY, U.K.

5. Eli Lilly and Company, Indianapolis, Indiana 46285, United States

Funder

Division of Chemistry

American Chemical Society

Wayne State University

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.8b02418

Reference63 articles.

1. Lead discovery and optimization strategies for peptide macrocycles

2. Systematic Targeting of Protein–Protein Interactions

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4. Targeting intracellular protein–protein interactions with cell-permeable cyclic peptides

5. Strategies for transitioning macrocyclic peptides to cell-permeable drug leads

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