Convergent Synthesis of PI3K Inhibitor GDC-0908 Featuring Palladium-Catalyzed Direct C–H Arylation toward Dihydrobenzothienooxepines-Reference-Cited by-同舟云学术

Convergent Synthesis of PI3K Inhibitor GDC-0908 Featuring Palladium-Catalyzed Direct C–H Arylation toward Dihydrobenzothienooxepines

Published:2018-12-13 Issue:8 Volume:84 Page:4796-4802
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Zhang Haiming¹^ORCID,Li Beryl X.¹,Wong Brian¹,Stumpf Andreas¹,Sowell C. Gregory¹,Gosselin Francis¹^ORCID

Affiliation:

1. Department of Small Molecule Process Chemistry, Genentech, Inc., 1 DNA Way, South San Francisco, California 94080, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.8b02751

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5. Blaquiere, N.; Do, S.; Dudley, D.; Folkes, A. J.; Goldsmith, R. A.; Heald, R.; Heffron, T.; Kolesnikov, A.; Ndubaku, C.; Olivero, A. G.; Price, S.; Staben, S.; Wei, B. Benzoxepin derivatives as PI3K inhibitor and their preparation and use in the treatment of cancer. PCT Int. Appl. 2011036284.

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