Stereoselective Synthesis of Four Calcitriol Lactone Diastereomers at C23 and C25-Reference-Cited by-同舟云学术

Stereoselective Synthesis of Four Calcitriol Lactone Diastereomers at C23 and C25

Published:2019-04-15 Issue:12 Volume:84 Page:7630-7641
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Nagata Akiko¹,Akagi Yusuke¹,Masoud Shadi Sedghi¹,Yamanaka Masahiro²^ORCID,Kittaka Atsushi³,Uesugi Motonari⁴^ORCID,Odagi Minami¹,Nagasawa Kazuo¹^ORCID

Affiliation:

1. Department of Biotechnology and Life Science, Graduate School of Technology, Tokyo University of Agriculture and Technology, 2-24-16, Naka-cho, Koganei City 184-8588, Tokyo, Japan

2. Department of Chemistry, Faculty of Science, Rikkyo University, 3-34-1 Nishi-Ikebukuro, Toshima-ku 171-8501, Tokyo, Japan

3. Faculty of Pharmaceutical Sciences, Teikyo University, 2-11-1 Kaga, Itabashi 173-8605, Tokyo, Japan

4. CREST, AMED, Chiyoda-ku 100-0004, Tokyo, Japan

Funder

Ministry of Education, Culture, Sports, Science and Technology

Core Research for Evolutional Science and Technology

Japan Agency for Medical Research and Development

Japan Society for the Promotion of Science

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.9b00403

Reference41 articles.

1. Metabolic pathways from 1 alpha,25-dihydroxyvitamin D3 to 1 alpha,25-dihydroxyvitamin D3-26,23-lactone. Stereo-retained and stereo-selective lactonization.

2. Dual metabolic pathway of 25-hydroxyvitamin D3 catalyzed by human CYP24

3. Novel Metabolism of 1α,25-Dihydroxyvitamin D3 with C24−C25 Bond Cleavage Catalyzed by Human CYP24A1

4. Nonclassic Actions of Vitamin D

5. Vitamin D, disease and therapeutic opportunities

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