Asymmetric Synthesis of Spiropyrazolone-Fused Dihydrofuran-naphthoquinones Bearing Contiguous Stereocenters via a Michael Addition/Chlorination/Nucleophilic Substitution Sequence-Reference-Cited by-同舟云学术

Asymmetric Synthesis of Spiropyrazolone-Fused Dihydrofuran-naphthoquinones Bearing Contiguous Stereocenters via a Michael Addition/Chlorination/Nucleophilic Substitution Sequence

Published:2023-03-22 Issue:7 Volume:88 Page:4809-4813
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Li Gaihui¹,Zhang Hongyu¹,Zhang Guoshun¹^ORCID,Wei Bei¹,Liu Bin¹,Song Heng¹²^ORCID,Li Qingshan¹³,Ban Shurong¹^ORCID

Affiliation:

1. School of Pharmacy, Shanxi Medical University, Taiyuan, Shanxi 030001, China

2. College of Chemistry and Molecular Sciences, Wuhan University, Wuhan 430072, China

3. Shanxi Key laboratory of Chronic Inflammatory Targeted Drugs, Shanxi University of Traditional Chinese Medicine, Jinzhong, Shanxi 030619, China

Funder

Ministry of Science and Technology of the People's Republic of China

National Natural Science Foundation of China

Primary Research and Development Plan of Shanxi Province

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acs.joc.2c03013

Reference44 articles.

1. Catalytic Asymmetric Synthesis of Spiropyrazolones and their Application in Medicinal Chemistry

2. A phosphodiesterase 4 inhibitor, roflumilast N-oxide, inhibits human lung fibroblast functions in vitro

3. Asymmetric synthesis of pyrazoles and pyrazolones employing the reactivity of pyrazolin-5-one derivatives

4. Enantioselective Synthesis of Spiropyrazolone-Fused Cyclopenta[c]chromen-4-ones Bearing Five Contiguous Stereocenters via (3+2) Cycloaddition

5. Pharmacophore modeling, 3D-QSAR, and docking study of pyrozolo[1,5-a]pyridine/4,4-dimethylpyrazolone analogues as PDE4 selective inhibitors

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