Discovery of a Potent Inhibitor of the Antiapoptotic Protein Bcl-xL from NMR and Parallel Synthesis-Reference-Cited by-同舟云学术

Discovery of a Potent Inhibitor of the Antiapoptotic Protein Bcl-xL from NMR and Parallel Synthesis

Published:2005-12-20 Issue:2 Volume:49 Page:656-663
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Petros Andrew M.¹,Dinges Jurgen¹,Augeri David J.¹,Baumeister Steven A.¹,Betebenner David A.¹,Bures Mark G.¹,Elmore Steven W.¹,Hajduk Philip J.¹,Joseph Mary K.¹,Landis Shelley K.¹,Nettesheim David G.¹,Rosenberg Saul H.¹,Shen Wang¹,Thomas Sheela¹,Wang Xilu¹,Zanze Irini¹,Zhang Haichao¹,Fesik Stephen W.¹

Affiliation:

1. Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm0507532

Reference25 articles.

1. Apoptosis in the Pathogenesis and Treatment of Disease

2. The Bcl-2 Protein Family: Arbiters of Cell Survival

3. The Bcl-2 family: roles in cell survival and oncogenesis

Cited by 274 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Binding Affinity Determination in Drug Design: Insights from Lock and Key, Induced Fit, Conformational Selection, and Inhibitor Trapping Models;International Journal of Molecular Sciences;2024-06-28

2. Emerging and Re-emerging Warheads for Targeted Covalent Inhibitors: An Update;Journal of Medicinal Chemistry;2024-05-07

3. Linking ATP and allosteric sites to achieve superadditive binding with bivalent EGFR kinase inhibitors;Communications Chemistry;2024-02-20

4. Therapeutic biomarkers in acute myeloid leukemia: functional and genomic approaches;Frontiers in Oncology;2024-02-12

5. Perspectives on Nuclear Magnetic Resonance Spectroscopy in Drug Discovery Research;Journal of Medicinal Chemistry;2024-01-30