Discovery of 2-(6-{[(6-Fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-N-hydroxypyrimidine-5-carboxamide (CHR-3996), a Class I Selective Orally Active Histone Deacetylase Inhibitor-Reference-Cited by-同舟云学术

Discovery of 2-(6-{[(6-Fluoroquinolin-2-yl)methyl]amino}bicyclo[3.1.0]hex-3-yl)-N-hydroxypyrimidine-5-carboxamide (CHR-3996), a Class I Selective Orally Active Histone Deacetylase Inhibitor

Published:2010-11-16 Issue:24 Volume:53 Page:8663-8678
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Moffat David¹,Patel Sanjay¹,Day Francesca¹,Belfield Andrew¹,Donald Alastair¹,Rowlands Martin²,Wibawa Judata²,Brotherton Deborah¹,Stimson Lindsay²,Clark Vanessa¹,Owen Jo¹,Bawden Lindsay¹,Box Gary²,Bone Elisabeth¹,Mortenson Paul³,Hardcastle Anthea²,van Meurs Sandra¹,Eccles Suzanne²,Raynaud Florence²,Aherne Wynne²

Affiliation:

1. Chroma Therapeutics Ltd., 93 Milton Park, Abingdon, OX14 4RY, U.K.

2. Haddow Laboratories, Cancer Research UK, Centre for Cancer Therapeutics, The Institute for Cancer Research, 15 Cotswold Road, Belmont, Sutton, Surrey, SM2 5NG, U.K.

3. Evotec (UK) Ltd., 114 Milton Park, Abingdon, OX14 4SA, U.K.

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm101177s

Reference37 articles.

1. Histone Deacetylases: Unique Players in Shaping the Epigenetic Histone Code

2. Anticancer activities of histone deacetylase inhibitors

3. Histone Deacetylase Inhibitors

4. Histone Deacetylase Inhibitors: From Bench to Clinic

5. Histone Deacetylase Inhibitors: Development of Suberoylanilide Hydroxamic Acid (SAHA) for the Treatment of Cancers

Cited by 78 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. Targeting the epigenome with advanced delivery strategies for epigenetic modulators;Bioengineering & Translational Medicine;2024-08-17

2. The Histone Deacetylase Family: Structural Features and Application of Combined Computational Methods;Pharmaceuticals;2024-05-10

3. Organocatalytic Diastereoselective Synthesis of Spiro[3-azabicyclo[3.1.0]hexanes] via 1,3-Dipolar Cycloaddition of Azomethine Ylides with Cyclopropenes;Russian Journal of General Chemistry;2024-04

4. Harnessing pyrimidine as a building block for histone deacetylase inhibitors;Archiv der Pharmazie;2023-07-18

5. Recent advancement of HDAC inhibitors against breast cancer;Medical Oncology;2023-06-09