A New Target for an Old Drug: Identifying Mitoxantrone as a Nanomolar Inhibitor of PIM1 Kinase via Kinome-Wide Selectivity Modeling-Reference-Cited by-同舟云学术

A New Target for an Old Drug: Identifying Mitoxantrone as a Nanomolar Inhibitor of PIM1 Kinase via Kinome-Wide Selectivity Modeling

Published:2013-03-15 Issue:6 Volume:56 Page:2619-2629
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Wan Xiaobo¹²,Zhang Wei²,Li Li²,Xie Yuting²,Li Wei¹²,Huang Niu¹²

Affiliation:

1. Graduate School of Peking Union Medical College and Chinese Academy of Medical Sciences, Beijing, China

2. National Institute of Biological Sciences, Beijing, No. 7 Science Park Road, Zhongguancun Life Science Park, Changping District, Beijing 102206, China

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm400045y

Reference71 articles.

1. Protein Kinase Inhibitors: Structural Insights Into Selectivity

2. Selectively Nonselective Kinase Inhibition: Striking the Right Balance

3. BAY 43-9006 Exhibits Broad Spectrum Oral Antitumor Activity and Targets the RAF/MEK/ERK Pathway and Receptor Tyrosine Kinases Involved in Tumor Progression and Angiogenesis

4. Life Beyond Kinases: Structure-Based Discovery of Sorafenib as Nanomolar Antagonist of 5-HT Receptors

5. High Affinity Targets of Protein Kinase Inhibitors Have Similar Residues at the Positions Energetically Important for Binding

Cited by 55 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. The mitochondrial calcium uniporter: Balancing tumourigenic and anti‐tumourigenic responses;The Journal of Physiology;2024-06-10

2. Exploring the Anti‐Cancer Potential of Hispidin: A Comprehensive in Silico and in Vitro Study on Human Osteosarcoma Saos2 Cells;Chemistry & Biodiversity;2024-04-11

3. Mitoxantrone and abacavir: An ALK protein-targeted in silico proposal for the treatment of non-small cell lung cancer;PLOS ONE;2024-02-06

4. Structure-Based Identification of Organoruthenium Compounds as Nanomolar Antagonists of Cannabinoid Receptors;Journal of Chemical Information and Modeling;2024-01-12

5. Targeting the Ubiquitin–Proteasome System and Recent Advances in Cancer Therapy;Cells;2023-12-22