A Focused DNA-Encoded Chemical Library for the Discovery of Inhibitors of NAD+-Dependent Enzymes

Author:

Yuen Lik Hang1,Dana Srikanta1ORCID,Liu Yu2,Bloom Samuel I.2,Thorsell Ann-Gerd3,Neri Dario4,Donato Anthony J.2,Kireev Dmitri5ORCID,Schüler Herwig3ORCID,Franzini Raphael M.1ORCID

Affiliation:

1. Department of Medicinal Chemistry, University of Utah, 30 S 2000 E, Salt Lake City, Utah 84112, United States

2. Department of Internal Medicine, University of Utah, 500 Foothill Drive, Salt Lake City, Utah 84148, United States

3. Department of Biosciences and Nutrition, Karolinska Institutet, Hälsovägen 7c, 14157 Huddinge, Sweden

4. Department of Pharmaceutical Sciences, ETH Zürich, Vladimir Prelog Weg 3, 8093 Zürich, Switzerland

5. Center for Integrative Chemical Biology and Drug Discovery, UNC Eshelman School of Pharmacy, University of North Carolina, Chapel Hill, North Carolina 27599, United States

Funder

Vetenskapsr?det

Cancerfonden

Eshelman Institute for Innovation, University of North Carolina

Huntsman Cancer Institute

University of Utah

American Association of Colleges of Pharmacy

IngaBritt och Arne Lundbergs Forskningsstiftelse

National Institute on Aging

Utah Science Technology and Research

Center of Aging, University of Utah

Publisher

American Chemical Society (ACS)

Subject

Colloid and Surface Chemistry,Biochemistry,General Chemistry,Catalysis

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