1. Laboratory of Cancer Cell Biology, Research Institute for Disease Mechanism and Control, First Department of Surgery, and Equipment Center for Research and Education, Nagoya University School of Medicine, Tsurumai 65, Showa-ku, Nagoya, 466-8550, Japan, Graduated School of Pharmaceutical Sciences, Hokkaido University, Sapporo, 060-0812, Japan, and Graduated School of Science and Technology, Kumamoto University, Kurokami, Kumamoto, 860-8555, Japan