Structure-Based Design of Novel 2-Amino-6-phenyl-pyrimido[5′,4′:5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as Potent and Orally Active Inhibitors of Lymphocyte Specific Kinase (Lck): Synthesis, SAR, and In Vivo Anti-Inflammatory Activity-Reference-Cited by-同舟云学术

Structure-Based Design of Novel 2-Amino-6-phenyl-pyrimido[5′,4′:5,6]pyrimido[1,2-a]benzimidazol-5(6H)-ones as Potent and Orally Active Inhibitors of Lymphocyte Specific Kinase (Lck): Synthesis, SAR, and In Vivo Anti-Inflammatory Activity

Published:2008-02-16 Issue:6 Volume:51 Page:1637-1648
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Martin Matthew W.¹,Newcomb John¹,Nunes Joseph J.¹,Boucher Christina¹,Chai Lilly¹,Epstein Linda F.¹,Faust Theodore¹,Flores Sylvia¹,Gallant Paul¹,Gore Anu¹,Gu Yan¹,Hsieh Faye¹,Huang Xin¹,Kim Joseph L.¹,Middleton Scot¹,Morgenstern Kurt¹,Oliveira-dos-Santos Antonio¹,Patel Vinod F.¹,Powers David¹,Rose Paul¹,Tudor Yanyan¹,Turci Susan M.¹,Welcher Andrew A.¹,Zack Debra¹,Zhao Huilin¹,Zhu Li¹,Zhu Xiaotian¹,Ghiron Chiara¹,Ermann Monika¹,Johnston David¹,Saluste Carl-Gustaf Pierre¹

Affiliation:

1. Department of Medicinal Chemistry, Department of HTS and Molecular Pharmacology, and Department of Molecular Structure, Amgen Inc., One Kendall Square, Building 1000, Cambridge, Massachusetts 02139, Department of Inflammation, Department of Pharmaceutics, Department of Pharmacokinetics and Drug Metabolism, Department of HTS and Molecular Pharmacology, and Department of Molecular Sciences, Amgen Inc., One Amgen Center Drive, Thousand Oaks, California 91320, and Evotec OAI, 151 Milton Park, Abingdon, Oxon...

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm701095m

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4. Fyn Can Partially Substitute for Lck in T Lymphocyte Development

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