Discovery of (5S,6S,9R)-5-Amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate (BMS-927711): An Oral Calcitonin Gene-Related Peptide (CGRP) Antagonist in Clinical Trials for Treating Migraine-Reference-Cited by-同舟云学术

Discovery of (5S,6S,9R)-5-Amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate (BMS-927711): An Oral Calcitonin Gene-Related Peptide (CGRP) Antagonist in Clinical Trials for Treating Migraine

Published:2012-11-15 Issue:23 Volume:55 Page:10644-10651
ISSN:0022-2623
Container-title:Journal of Medicinal Chemistry
language:en
Short-container-title:J. Med. Chem.

Author:

Luo Guanglin¹,Chen Ling¹,Conway Charles M.¹,Denton Rex¹,Keavy Deborah¹,Signor Laura¹,Kostich Walter¹,Lentz Kimberley A.¹,Santone Kenneth S.¹,Schartman Richard¹,Browning Marc¹,Tong Gary¹,Houston John G.¹,Dubowchik Gene M.¹,Macor John E.¹

Affiliation:

1. Molecular Sciences and Candidate Optimization, Disease Sciences and Biologics, Bristol-Myers Squibb Research & Development, 5 Research Parkway, Wallingford, Connecticut 06492, United States

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/jm3013147

Reference23 articles.

1. Burden of Migraine in the United States

2. MECHANISM OF MIGRAINE HEADACHE AND ACTION OF ERGOTAMINE TARTRATE

3. Origin of pain in migraine: evidence for peripheral sensitisation

4. Neurobiology of migraine

5. Neuroanatomical Localization, Pharmacological Characterization and Functions of CGRP, Related Peptides and Their Receptors

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