Transition States and Energetics of Nucleophilic Additions of Thiols to Substituted α,β-Unsaturated Ketones: Substituent Effects Involve Enone Stabilization, Product Branching, and Solvation-Reference-Cited by-同舟云学术

Transition States and Energetics of Nucleophilic Additions of Thiols to Substituted α,β-Unsaturated Ketones: Substituent Effects Involve Enone Stabilization, Product Branching, and Solvation

Published:2011-05-16 Issue:12 Volume:76 Page:5074-5081
ISSN:0022-3263
Container-title:The Journal of Organic Chemistry
language:en
Short-container-title:J. Org. Chem.

Author:

Krenske Elizabeth H.¹²,Petter Russell C.³,Zhu Zhendong³,Houk K. N.²

Affiliation:

1. School of Chemistry, University of Melbourne, and Australian Research Council Centre of Excellence for Free Radical Chemistry and Biotechnology, VIC 3010, Australia

2. Department of Chemistry and Biochemistry, University of California, Los Angeles, California 90095, United States

3. Avila Therapeutics, 100 Beaver Street, Waltham, Massachusetts 02453, United States

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/jo200761w

Reference92 articles.

1. New synthetic methods. Secoalkylative approach to grandisol

2. Tandem Michael/intramolecular aldol reactions mediated by secondary amines, thiols and phosphines

3. Enantioselective Conjugate Additions