1. CRC Gene Targeted Drug Design Research Group, School of Pharmacy and Biomedical Science, University of Portsmouth, St Michael's Building, White Swan Road, Portsmouth, Hants. PO1 2DT, U.K., CRC Biomolecular Structure Unit, Institute of Cancer Research, Sutton, Surrey SM2 5NG, U.K., CRC Drug−DNA Interactions Research Group, Department of Oncology, University College London Medical School, 91 Riding House Street, London W1P 8BT, U.K., and College of Pharmacy, University of Texas at Austin, Austin, Texas 78712