A pH-Dilution Method for Estimation of Biorelevant Drug Solubility along the Gastrointestinal Tract: Application to Physiologically Based Pharmacokinetic Modeling-Reference-Cited by-同舟云学术

A pH-Dilution Method for Estimation of Biorelevant Drug Solubility along the Gastrointestinal Tract: Application to Physiologically Based Pharmacokinetic Modeling

Published:2010-08-17 Issue:5 Volume:7 Page:1516-1526
ISSN:1543-8384
Container-title:Molecular Pharmaceutics
language:en
Short-container-title:Mol. Pharmaceutics

Author:

Gao Yi¹,Carr Robert A.¹,Spence Julie K.¹,Wang Weili W.¹,Turner Teresa M.¹,Lipari John M.¹,Miller Jonathan M.¹

Affiliation:

1. Global Pharmaceutical Research and Development, Abbott Laboratories, Abbott Park, Illinois 60064

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Pharmaceutical Science,Molecular Medicine

Link

https://pubs.acs.org/doi/pdf/10.1021/mp100157s

Reference63 articles.

1. A compartmental absorption and transit model for estimating oral drug absorption

2. Application of Full Physiological Models for Pharmaceutical Drug Candidate Selection and Extrapolation of Pharmacokinetics to Man

3. An Evaluation of the Utility of Physiologically Based Models of Pharmacokinetics in Early Drug Discovery

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