Synthesis and Antibacterial Activity of Novel Pyrido[1,2,3-de][1,4]benzoxazine-6-carboxylic Acid Derivatives Carrying the 3-Cyclopropylaminomethyl-4-substituted-1-pyrrolidinyl Group as a C-10 Substituent

Author:

Asahina Yoshikazu1,Takei Masaya1,Kimura Tetsuya1,Fukuda Yasumichi1

Affiliation:

1. Discovery Research Laboratories, Kyorin Pharmaceutical Co. Ltd., 2399-1, Nogi, Nogi-Machi, Shimotsuga-Gun, Tochigi, 329-0114, Japan

Publisher

American Chemical Society (ACS)

Subject

Drug Discovery,Molecular Medicine

Reference39 articles.

1. Structure-activity relationships of antibacterial 6,7- and 7,8-disubstituted 1-alkyl-1,4-dihydro-4-oxoquinoline-3-carboxylic acids

2. aHirai, K.; Hosaka, M.; Niwata, Y.; Yasue, T.; Fukuda, H.; Ishizaki, T.; Suzue, S.; Nishino, K.Antibacterial Activity of AM-1155, a New Quinolone. Presented at the30th Meeting of the ICAAC,Atlanta, GA,1990; Abstract 385.

3. In vitro and in vivo antibacterial activities of AM-1155, a new 6-fluoro-8-methoxy quinolone

4. Peterson, U.; Bremm, K. D.; Dalhoff, A.; Endermann, R.; Heilmann, W.; Krebs, A.; Schenke, T.Synthesis and in Vitro Activity of BAY 12-8039, a New 8-Methoxy-Quinlone. Presented at the36th Meeting of the ICAAC,New Orleans, LA,1996; Abstract F1.

5. Gootz, T. D.; Brighty, K. E.; Anderson, M. R.; Haskell, S. L.; Sutcliffe, J. A.; Castaldi, M. J.; Miller, S. A.In Vitro Activity and Synthesis of CP-99219, a Novel 7-(3-Azabicyclo[3.1.0]hexyl)naphthyridine. Presented at the32th Meeting of the ICAAC,Anaheim, CA,1992; Abstract 751.

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