Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor-Reference-Cited by-同舟云学术

Discovery of a Pyrrolopyrimidine (JH-II-127), a Highly Potent, Selective, and Brain Penetrant LRRK2 Inhibitor

Published:2015-04-13 Issue:5 Volume:6 Page:584-589
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Hatcher John M.¹²,Zhang Jinwei³,Choi Hwan Geun¹,Ito Genta³,Alessi Dario R.³,Gray Nathanael S.¹²

Affiliation:

1. Department of Cancer Biology, Dana-Farber Cancer Institute, Boston, Massachusetts 02115, United States

2. Department of Biological Chemistry & Molecular Pharmacology, Harvard Medical School, 360 Longwood Avenue, Longwood Center LC-2209, Boston, Massachusetts 02115, United States

3. MRC Protein Phosphorylation Unit, College of Life Sciences, University of Dundee, Dow Street, Dundee DD1 5EH, Scotland, United Kingdom

Funder

Michael J. Fox Foundation for Parkinson's Research

National Institute of General Medical Sciences

Medical Research Council

National Cancer Institute

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.5b00064

Reference31 articles.

1. Leucine-rich repeat kinase 2 (LRRK2): A key player in the pathogenesis of Parkinson's disease

2. Projected number of people with Parkinson disease in the most populous nations, 2005 through 2030

3. Limitations of current Parkinson's disease therapy

4. On the Road to Leucine-Rich Repeat Kinase 2 Signalling: Evidence from Cellular and in vivo Studies

5. Phenotype, genotype, and worldwide genetic penetrance of LRRK2-associated Parkinson's disease: a case-control study

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