SAR Studies of 5-Aminopyrazole-4-carboxamide Analogues as Potent and Selective Inhibitors of Toxoplasma gondii CDPK1

Author:

Huang Wenlin1,Ojo Kayode K.2,Zhang Zhongsheng1,Rivas Kasey2,Vidadala Rama Subba Rao3,Scheele Suzanne4,DeRocher Amy E.4,Choi Ryan2,Hulverson Matthew A.2,Barrett Lynn K.2,Bruzual Igor5,Siddaramaiah Latha Kallur1,Kerchner Keshia M.1,Kurnick Matthew D.6,Freiberg Gail M.6,Kempf Dale6,Hol Wim G. J.1,Merritt Ethan A.1,Neckermann Georg7,de Hostos Eugenio L.7,Isoherranen Nina8,Maly Dustin J.3,Parsons Marilyn49,Doggett J. Stone5,Van Voorhis Wesley C.29,Fan Erkang1

Affiliation:

1. Department of Biochemistry, University of Washington, Seattle, Washington 98195, United States

2. Department of Medicine, Division of Allergy and Infectious Diseases, and the Center for Emerging and Re-emerging Infectious Diseases (CERID), University of Washington, Seattle, Washington 98109, United States

3. Department of Chemistry, University of Washington, Seattle, Washington 98195, United States

4. Center for Infectious Disease Research (formerly Seattle Biomedical Research Institute), Seattle, Washington 98109, United States

5. Portland VA Medical Center, Portland, Oregon 97239, United States

6. AbbVie, N. Chicago, Illinois 60064, United States

7. PATH, San Francisco, California 94102, United States

8. Department of Pharmaceutics, University of Washington, Seattle, Washington 98195, United States

9. Department of Global Health, University of Washington, Seattle, Washington 98195, United States

Funder

U.S. Department of Veterans Affairs

Basic Energy Sciences

National Institute of Allergy and Infectious Diseases

National Institute of Child Health and Human Development

National Institute of General Medical Sciences

U.S. Department of Agriculture

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

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