Discovery of Pyrazolo[1,5-a]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent-Reference-Cited by-同舟云学术

Discovery of Pyrazolo[1,5-a]pyrimidine TTK Inhibitors: CFI-402257 is a Potent, Selective, Bioavailable Anticancer Agent

Published:2016-05-06 Issue:7 Volume:7 Page:671-675
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Liu Yong¹,Laufer Radoslaw¹,Patel Narendra Kumar¹,Ng Grace¹,Sampson Peter B.¹,Li Sze-Wan¹,Lang Yunhui¹,Feher Miklos¹,Brokx Richard¹,Beletskaya Irina¹,Hodgson Richard¹,Plotnikova Olga¹,Awrey Donald E.¹,Qiu Wei²,Chirgadze Nickolay Y.²,Mason Jacqueline M.¹,Wei Xin¹,Lin Dan Chi-Chia¹,Che Yi¹,Kiarash Reza¹,Fletcher Graham C.¹,Mak Tak W.¹,Bray Mark R.¹,Pauls Henry W.¹

Affiliation:

1. Campbell Family Institute for Breast Cancer Research, University Health Network, TMDT East Tower, MaRS Centre, 101 College Street, Toronto, Ontario M5G 1L7, Canada

2. Campbell Family Cancer Research Institute, University Health Network, Princess Margaret Cancer Center, 610 University Avenue, Toronto, Ontario M5G 2C4, Canada

Funder

Government of Canada

Princess Margaret Cancer Foundation

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.5b00485

Reference26 articles.

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2. The Discovery of Orally Bioavailable Tyrosine Threonine Kinase (TTK) Inhibitors: 3-(4-(heterocyclyl)phenyl)-1H-indazole-5-carboxamides as Anticancer Agents

3. Mak, T. W.Targeting the Cell Cycle in Cancer: TTK (MPS1) and PLK4 as Novel Mitotic Targets. AACR 103rd Annual Meeting, Chicago, IL, April 1–5, 2012.

4. Lethality to human cancer cells through massive chromosome loss by inhibition of the mitotic checkpoint

5. Mps1 Is a Kinetochore-Associated Kinase Essential for the Vertebrate Mitotic Checkpoint

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