Novel Macrocyclic Antagonists of the CGRP Receptor Part 2: Stereochemical Inversion Induces an Unprecedented Binding Mode-Reference-Cited by-同舟云学术

Novel Macrocyclic Antagonists of the CGRP Receptor Part 2: Stereochemical Inversion Induces an Unprecedented Binding Mode

Published:2022-10-19 Issue:11 Volume:13 Page:1776-1782
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Southall Stacey M.¹,Banerjee Joydeep²,Brown Jason¹,Butkovic Kristina³,Cansfield Andrew D.¹,Cansfield Julie E.¹,Congreve Miles S.¹,Cseke Gabriella¹,Deflorian Francesca¹,Hunjadi Martina Petrovic³,Hutinec Antun³,Inturi Trinadh Kumar²,Rupcic Renata³,Saxty Gordon³,Watson Stephen P.¹^ORCID

Affiliation:

1. Sosei Heptares, Steinmetz Building, Granta Park, Great Abington, Cambridge CB21 6DG, United Kingdom

2. Syngene International, Biocon Park, Bommasandra, Bangalore, Karnataka 560099, India

3. Selvita d.o.o., Prilaz aruna Filipovića 29, 10000 Zagreb, Croatia

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.2c00400

Reference21 articles.

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2. Comparative Efficacy of Oral Calcitonin-Gene–Related Peptide Antagonists for the Treatment of Acute Migraine: Updated Meta-analysis

3. Characterization of Ubrogepant: A Potent and Selective Antagonist of the Human Calcitonin Gene‒Related Peptide Receptor*

4. Discovery of (5S,6S,9R)-5-Amino-6-(2,3-difluorophenyl)-6,7,8,9-tetrahydro-5H-cyclohepta[b]pyridin-9-yl 4-(2-oxo-2,3-dihydro-1H-imidazo[4,5-b]pyridin-1-yl)piperidine-1-carboxylate (BMS-927711): An Oral Calcitonin Gene-Related Peptide (CGRP) Antagonist in Clinical Trials for Treating Migraine

5. Oral rimegepant for preventive treatment of migraine: a phase 2/3, randomised, double-blind, placebo-controlled trial

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