Conformational-Design-Driven Discovery of EZM0414: A Selective, Potent SETD2 Inhibitor for Clinical Studies
Author:
Affiliation:
1. Epizyme Inc., 50 Hampshire Street, Sixth Floor, Cambridge, Massachusetts 02139, United States
Funder
Epizyme
Publisher
American Chemical Society (ACS)
Subject
Organic Chemistry,Drug Discovery,Biochemistry
Link
https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.2c00167
Reference20 articles.
1. Histone Methyltransferases as Therapeutic Targets for Kidney Diseases
2. SETD2: an epigenetic modifier with tumor suppressor functionality
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4. SETD2 alterations impair DNA damage recognition and lead to resistance to chemotherapy in leukemia
5. Genetic and Functional Drivers of Diffuse Large B Cell Lymphoma
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