High-Throughput Assessment of Bile Salt Export Pump Inhibition Using RapidFire-MS and DESI-MS-Reference-Cited by-同舟云学术

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High-Throughput Assessment of Bile Salt Export Pump Inhibition Using RapidFire-MS and DESI-MS

Published:2024-08-12 Issue: Volume: Page:
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Li Jie¹²^ORCID,Morato Nicolás M.²^ORCID,Westover Lori S.³,Abeywickrema Pravien³,Geng Jieping³,Piassek Madison³,Harden David³,Strambeanu Iulia¹^ORCID,Shi Zhicai¹,Cooks R. Graham²^ORCID,Meng Juncai³^ORCID

Affiliation:

1. Global Discovery Chemistry, Janssen Research and Development, Spring House, Pennsylvania 19477, United States

2. Department of Chemistry, Purdue University, West Lafayette, Indiana 47907, United States

3. Discovery Technology and Molecular Pharmacology, Janssen Research and Development, Spring House, Pennsylvania 19477, United States

Funder

Janssen Research and Development

Purdue University

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.4c00302

Reference49 articles.

1. Drug-induced liver injury

2. Assessment of Bile Salt Export Pump (BSEP) Inhibition in Membrane Vesicles Using Radioactive and LC/MS‐Based Detection Methods

3. Drug-Induced Liver Injury: Review Article

4. Minimizing DILI risk in drug discovery — A screening tool for drug candidates

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