Discovery of CVN293, a Brain Permeable KCNK13 (THIK-1) Inhibitor Suitable for Clinical Assessment-Reference-Cited by-同舟云学术

Discovery of CVN293, a Brain Permeable KCNK13 (THIK-1) Inhibitor Suitable for Clinical Assessment

Published:2024-04-05 Issue:5 Volume:15 Page:646-652
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Bürli Roland W.¹,Doyle Kevin J.¹,Dickson Louise¹^ORCID,Rowland Anna¹,Matthews Kim¹,Stott Andrew J.¹,Teall Martin¹,Ossola Bernardino¹^ORCID,Russell Samuel G.¹,Harvey Jenna R. M.¹,Wu Yiming²,Narayana Lakshminarayana³,Brice Nicola L.¹,Carlton Mark¹,Dawson Lee A.¹

Affiliation:

1. Cerevance Limited, 418 Cambridge Science Park, Cambridge, CB4 0PZ, United Kingdom

2. Wuxi Apptec Co., Ltd., 288 Fute Zhong Rd., Waigaoqiao, Shanghai 200131, People’s Republic of China

3. Aragen Life Sciences Ltd, Plot #284A (part), Bommasandra-Jigani Link Road Industrial Area, Bengaluru 562106, India

Funder

Cerevance Limited

Publisher

American Chemical Society (ACS)

Link

https://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.4c00035

Reference10 articles.

1. Inflammasome signalling in brain function and neurodegenerative disease

2. Key Mechanisms and Potential Targets of the NLRP3 Inflammasome in Neurodegenerative Diseases

3. Strategies for Targeting the NLRP3 Inflammasome in the Clinical and Preclinical Space

4. Microglial Ramification, Surveillance, and Interleukin-1β Release Are Regulated by the Two-Pore Domain K+ Channel THIK-1

5. The two pore potassium channel THIK ‐1 regulates NLRP3 inflammasome activation

Cited by 1 articles. 订阅此论文施引文献订阅此论文施引文献，注册后可以免费订阅5篇论文的施引文献，订阅后可以查看论文全部施引文献

1. CryoEM Structure of the human THIK-1 K2P K⁺Channel Reveals a Lower ‘Y-gate’ Regulated by Lipids and Anaesthetics;2024-06-27