Discovery of AZD2716: A Novel Secreted Phospholipase A2 (sPLA2) Inhibitor for the Treatment of Coronary Artery Disease-Reference-Cited by-同舟云学术

Discovery of AZD2716: A Novel Secreted Phospholipase A2 (sPLA2) Inhibitor for the Treatment of Coronary Artery Disease

Published:2016-08-22 Issue:10 Volume:7 Page:884-889
ISSN:1948-5875
Container-title:ACS Medicinal Chemistry Letters
language:en
Short-container-title:ACS Med. Chem. Lett.

Author:

Giordanetto Fabrizio¹,Pettersen Daniel¹,Starke Ingemar¹,Nordberg Peter¹,Dahlström Mikael¹,Knerr Laurent¹,Selmi Nidhal¹,Rosengren Birgitta¹,Larsson Lars-Olof¹,Sandmark Jenny¹,Castaldo Marie¹,Dekker Niek¹,Karlsson Ulla¹,Hurt-Camejo Eva¹

Affiliation:

1. Cardiovascular and Metabolic Diseases, Innovative Medicines and Early Development Biotech Unit Departments of Medicinal Chemistry, ‡Bioscience, §DMPK, ∥Discovery Sciences Departments of Structure & Biophysics, ⊥Reagents and Assay Development, and #Screening Sciences and Sample Management, Astrazeneca, Mölndal, Pepparedsleden 1, SE-431 83 Mölndal, Sweden

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

Link

http://pubs.acs.org/doi/pdf/10.1021/acsmedchemlett.6b00188

Reference26 articles.

1. A new era of secreted phospholipase A2

2. Interfacial Kinetic and Binding Properties of the Complete Set of Human and Mouse Groups I, II, V, X, and XII Secreted Phospholipases A2

3. Recent progress in phospholipase A2 research: From cells to animals to humans

4. Expression of secretory phospholipase A2s in human atherosclerosis development

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