Conversion of a PROTAC Mutant Huntingtin Degrader into Small-Molecule Hydrophobic Tags Focusing on Drug-like Properties

Author:

Hirai Keigo1,Yamashita Hiroko2,Tomoshige Shusuke1ORCID,Mishima Yugo1,Niwa Tatsuya3,Ohgane Kenji2ORCID,Ishii Mayumi4,Kanamitsu Kayoko4,Ikemi Yui5,Nakagawa Shinsaku5,Taguchi Hideki3ORCID,Sato Shinichi16ORCID,Hashimoto Yuichi2,Ishikawa Minoru1ORCID

Affiliation:

1. Graduate School of Life Sciences, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan

2. Institute for Quantitative Biosciences, The University of Tokyo, 1-1-1 Yayoi, Bunkyo-ku, Tokyo 113-032, Japan

3. Cell Biology Center, Institute of Innovative Research, Tokyo Institute of Technology, 4259 Nagatsuta-Cho, Midori-ku, Yokohama, Kanagawa 226-8503, Japan

4. Drug Discovery Initiative, The University of Tokyo, 7-3-1 Hongo, Bunkyo-ku, Tokyo 113-0033, Japan

5. Center for Supporting Drug Discovery and Life Science Research, Graduate School of Pharmaceutical Sciences, Osaka University, 1-6 Yamadaoka, Suita, Osaka 565-0871, Japan

6. Frontier Research Institute for Interdisciplinary Sciences, Tohoku University, 2-1-1 Katahira, Aoba-ku, Sendai, Miyagi 980-8577, Japan

Funder

Japan Agency for Medical Research and Development

Ministry of Education, Culture, Sports, Science and Technology

Uehara Memorial Foundation

Publisher

American Chemical Society (ACS)

Subject

Organic Chemistry,Drug Discovery,Biochemistry

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